Doctor's Best - Nattokinase - 270 V-Caps (2,000 FU)

What is Doctor’s Best Nattokinase?

Nattokinase is a proteolytic enzyme with research on its health benefits spanning decades. Proteolytic enzymes, as the term implies, break down proteins Nattokinase was discovered in the 1980s when Dr. Hiroyuki Sumi studied 173 kinds of natural foods to find a suitable protease enzyme to support circulatory health.

Health Key Benefits of Doctor’s Best Nattokinase

Nattokinase Supplements Make Their Way into the Bloodstream

A human clinical trial intended to (1) detect nattokinase directly and immunologically, (2) show that nattokinase and/or its metabolites were detectable in human blood following ingestion of a commercial preparation, and (3) chart a pharmacokinetic dosing effect for nattokinase. Eleven healthy human subjects (five male, six female, ages 21-65) orally ingested a 2000 FU nattokinase capsule immediately following a baseline draw. Subsequent blood draws occurred over 24 hours. The presence of nattokinase in serum was measured by an enzyme-linked immunosorbent assay (ELISA), using a rabbit, polyclonal, anti-nattokinase-capture antibody. A pharmacokinetic pattern was observed for nattokinase between baseline and 48 hours post dose. The researchers concluded that their results controlled scanning capillary rheometer (Rheolog). In vitro results showed a significant, dose-dependent decrease of RBC aggregation and low-shear viscosity, with these beneficial effects evident at concentrations similar to those achieved in previous in vivo animal trials. The study concluded that the data indicates positive in vitro effects of nattokinase and suggest its potential value as a therapeutic agent.

Supports Healthy Blood Pressure, Supports Healthy Circulation

The nattokinase in this formulation is proven from human and corroborative animal studies to support various aspects of the cardiovascular system. In a randomized, double blind, placebo-controlled trial, 86 men and women (ages 20-80) received one capsule per day for 8 weeks containing either nattokinase (at a dose of 2,000 fibrinolytic activity units) or placebo. This trial provided evidence that compared to placebo, nattokinase can significantly help to maintain a healthy blood pressure.